These guidelines are appropriate for adults (aged 18-64 years) with minimal to moderate disability resulting from either relapsing remitting or progressive forms of multiple sclerosis irrespective of gender, race, ethnicity or socio-economic status. People living with multiple sclerosis, their families, health care professionals and organizations that promote exercise or serve adults with multiple sclerosis may use these guidelines as a tool for making exercise recommendations or developing exercise programs.

Improved fitness is especially important for people with multiple sclerosis for whom rates of inactivity are high and deconditioning is common. Following these guidelines can improve aspects of fitness related to aerobic endurance and muscle strength. While participating in either aerobic activity or strength training will yield some specific fitness benefits, participating in both types of activity will yield a broader range of fitness benefits.

These guidelines refer to activities that should be performed in addition to usual activities of daily living. Adults with multiple sclerosis may wish to speak to a health professional to find out what types and amounts of physical activity are appropriate for them. Those who are pregnant or have other medical conditions in addition to multiple sclerosis should talk to a health professional before beginning an exercise program. A health professional might include a doctor, a physiotherapist, or a qualified exercise professional. Supervised exercise is advisable but not essential when starting or returning to exercise.

Meeting these guidelines may also reduce fatigue, improve mobility and enhance elements of health-related quality of life. Experts agree that currently there is no scientific evidence that following these guidelines will result in relapse of multiple sclerosis symptoms or worsen fatigue or health-related quality of life. The potential benefits exceed the potential risks associated with physical activity.